NUCLEOSIL® is a family of totally porous spherical silicas with a very pure and uniform SiO2 structure
- Wide acceptance as routine packings for very different fields of chromatography
- One of the first spherical silicas used in HPLC
- Developed in the early seventies, it became a world-renowned HPLC packing
- Still found in many analytical and preparative application
- An absolutely reliable choice in HPLC
- The largest variety of modified HPLC silicas available on the market
NUCLEOSIL® CN / CN-RP
Cyano (nitrile) modified silica phases for HPLC
USP L10
Features
- Polar to mid-polar cyano (nitrile) modified silica for reversed phase and normal phase chromatography
- Normal phase: with low-polarity solvents for many compounds, which can also be separated on unmodified silica, however, due to the rapid equilibration much more suitable for gradient separations
- Reversed phase: with different selectivity than C18, C8 or phenyl modified packings
- Available pore sizes 100 and 120 Å
- Available particle sizes 5 µm, 7 µm and 10 µm
- pH stability at 20 °C: 2–8
- Carbon content 5 % (100 Å), ~ 3 % (120 Å)
Eluent in column
- CN: n-heptane
- CN-RP: acetonitrile – water
Separation mechanism based on π–π interactions, polar interactions and hydrophobic interactions
Corresponding NUCLEODUR® phase see NUCLEODUR® CN / CN-RP