Restek chemists became the first to combine the speed of superficially porous particles (also known as SPP or “core-shell” particles) with the resolution of highly selective USLC technology. This new breed of chromatographic column allows you to more easily achieve peak separation and faster analysis times without expensive UHPLC instrumentation.
Designed and intended specifically for use on LC-MS/MS systems, the Raptor ARC-18 column offers a well-balanced retention profile without the drawbacks of using an ordinary C18 in the harsh, acidic mobile phases needed for mass spectrometry (MS). Even after extended use in these low-pH (≤ 2.0) conditions, the sterically protected ARC-18 offers consistent retention, peak shape, and response for charged bases, neutral acids, small polar compounds, and more. For the rapid analysis of large, multiclass assays by LC-MS/MS, the acid-resistant Raptor ARC-18 truly is ahead of the curve.
Stationary Phase Category: C18, octadecylsilane (L1)
Ligand Type: Sterically protected C18
Particle: 2.7 µm or 5 µm superficially porous silica (SPP or "core-shell")
Pore Size: 90 Å
Carbon Load: 7% (2.7 µm), 5% (5 µm)
End-Cap: no
Surface Area: 150 m2/g (2.7 µm) or 100 m2/g (5 µm)
Recommended Usage:
pH Range: 1.0–8.0
Maximum Temperature: 80°C
Maximum Pressure: 600 bar/8,700 psi (2.7 µm) or 400 bar/5,800 psi (5 µm)
Properties:
- Ideal for high-throughput LC-MS/MS applications with minimal sample preparation.
- Well-balanced retention profile for better detection and integration of large, multiclass analyte lists.
- Sterically protected to endure low-pH mobile phases without sacrificing retention or peak quality.
- Part of Restek’s Raptor LC column line featuring 1.8, 2.7, and 5 µm SPP core-shell silica.
Switch to an ARC-18 when:
- You are analyzing large, multiclass lists by LC-MS/MS
- Strongly acidic (pH 1–3) mobile phases are required
- Free-Turn architecture lets you change cartridges by hand without breaking inlet/outlet fluid connections—no tools needed
- Patented titanium hybrid ferrules can be installed repeatedly without compromising high-pressure seal
- Auto-adjusting design provides ZDV (zero dead volume) connection to any 10-32 female port
Maximum cartridge pressure: 1,034 bar/15,000 psi* (UHPLC), 600 bar/8,700 psi (2.7 μm); 400 bar/5,800 psi (5 μm)
* For maximum lifetime, recommended maximum pressure for UHPLC particles is 830 bar/12,000 psi.